DynaMatrix Plus
DynaMatrix® Plus is specifically designed for soft tissue grafting procedures.
- It is an extracellular matrix (ECM) derived from porcine small intestinal submucosa (8 layers SIS - twice the thickness of standard DynaMatrix®).
ECM contains two of the three essential biological components required for healing: matrix scaffold & signals, which include growth factors and ECM cell receptor-mediated binding sites. The biologic material guides the patient’s soft tissue to form organized tissue. It is a high-performing clinical alternative to connective tissue grafts, and eliminates the need to harvest tissue from the patient’s oral cavity.
Stronger Tissue Sooner
Retains the natural composition of matrix molecules such as collagen (Type I, III, IV, VI), glycosaminoglycans (hyaluronic acid), glycoproteins (fibronectin) and growth factors1,2
Regulates cell adhesion, migration, division and differentiation3,4,5
Facilitates angiogenesis6
Easy Handling & Bioactive Design
Both sides of DynaMatrix® Plus can be used interchangeably
SIS can be left exposed for tension-free closure
Drapes easily and flexible enough to be cut, rolled, folded, tacked or sutured
Completely remodels into strong, fully vascularized tissue 7,8
References
1. Hodde J, Janis A, Ernst D, Zopf D, Sherman D, Johnson C. Effects of sterilization on an extracellular matrix scaffold: part I. Composition and matrix architecture. J Mater Sci Mater Med. 2007 Apr;18(4):537-43.
2. Hodde JP, Ernst DM, Hiles MC. An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix. J Wound Care. 2005 Jan;14(1):23-5.
3. Lindberg K, Badylak SF. Porcine small intestinal submucosa (SIS): A bioscaffold supporting in vitro primary human epidermal cell differentiation and synthesis of basement membrane points. Burns 2001; 27:254-266.
4. Badylak S, Liang A, Record R, Tullius R, Hodde J. Endothelial cell adherence to small intestinal submucosa: An acellular bioscaffold. Biomaterials 1999; 20: 2257-2263.
5. Badylak SF, Park K, Peppas N, McCage G, Yoder M. Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix. Exp Hematol 2001; 19: 1301-1218.
6. Nihsen ES, Johnson CE, Hiles MC. Bioactivity of small intestinal submucosa and oxidized regenerated cellulose/collagen. Adv Skin Wound Care 2008; 21:479-486.
7. Rice RD, Ayubi FS, Shaub ZJ, Parker DM, Armstrong PJ, Tsai JW. Comparison of Surgisis, Alloderm, and Vicryl Woven Mesh Grafts for abdominal wall defect repair in an animal model. Aesthet Plast Surg. 2010;34:290-296.
8. Nevins M, Nevins ML, Camelo M, Camelo JM, Schupbach P, Kim DM. The Clinical Efficacy of DynaMatrix Extracellular Membrane in Augmenting Keratinized Tissue. Int J Periodontics Restorative Dent. 2010 Apr;30(2):151-61.
From A to Z
Resources
WE want to hear from you